To explore the effect and mechanism of ethanol extract of Hericium erinaceus on apoptosis of gastric cancer cells in rats. Sixty SD rats were selected, 10 as normal group, and the remaining 50 as gastric cancer models. They were divided into gastric cancer group, drug control group, low, medium and high concentration group of Monkey mushroom fungus. The cell proliferation, apoptosis and cycle distribution were observed, and the expressions of motilin, gastrin, Bcl-2, Bax and caspase-3 were detected. The results show that: The levels of motilin and gastrin in the high concentration group were 140.62 pg/mL and 85.39 pg/mL respectively, the apoptotic rate of tumor cells was 50.25%, the percentage of cells in G1 phase was 55.61% and the expression of Bax was 0.76, it was higher than that of gastric cancer group, drug control group, low and medium concentration of Hericium erinaceus groups. The proliferation rate of tumor cells in the high concentration group of Hericium erinaceus was 11.52%, The expressions of Bcl-2 and caspase-3 were 1.35 and 1.32 respectively, they were lower than those of gastric cancer group, drug control group, low and medium concentration of Hericium erinaceus groups (p<0.05). Ethanol extract of Hericium erinaceus can improve the gastric function of gastric cancer rats, regulate the proliferation, apoptosis and cycle distribution of gastric cancer cells, and provide a theoretical basis for clinical treatment of gastric cancer.
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