研究了柑橘皮黄酮对四氧嘧啶诱导的糖尿病小鼠的降血糖作用，并探讨了其部分作用机制。结果表明：给药10 d后，中、高剂量组的柑橘皮黄酮能极显著降低糖尿病小鼠的血清血糖值，提高其胸腺指数和脾指数，增强血清及肝脏中SOD活性，抑制MDA的产生，降低血浆中TG、TC和LDL-C含量，提高HDL-C含量，说明增强机体免疫力、抗氧化作用和改善脂代谢紊乱可能是柑橘皮黄酮降血糖的作用机制之一，为柑橘皮的开发利用提供理论依据。

The hypoglycemic effect of total flavonoids extracted from citrus peels on diabetic white mice induced by alloxan was studied and the preliminary mechanism was discussed. Results showed that after intragastric administration of middle and high dosage of total flavonoids extracted from citrus peels for 10 days, the concentration of blood glucose of alloxan-induced diabetic mice reduced obviously. Compared with the model group, the spleen index, thymus gland index, and the activity of superoxides dismutase (SOD) in blood and liver of the diabetic mice were increased and the formation of the malondialdehyde (MDA) were inhibited. The contents of TG, TC, and LDL-C decreased greatly, while the content of HDL-C increased obviously. The results suggested that the improvement of immunity, antioxidation, and regulation of lipid metabolism disorders in alloxan-induced diabetic white mice may be one of the hypoglycemic mechanisms of total flavonoids extracted from citrus peels, which provided a theoretical basis to the development and utilization of citrus peels.

国家科技支撑计划课题（2012BAD31B03）；广东省教育部产学研结合项目（2011A090200078）；广东省农业科技项目（LNSG2010-14）