Abstract:
The effects of Pu-erh tea extract, stigma maydis extract, oligofructose and their compound formula on glucose and lipid metabolism and insulin sensitivity in diabetic rats were investigated in this study. Eighty healthy adult male Sprague Dawley rats were randomly divided into 8 groups: The normal control group was given normal chow diet, the model control group, Pu'er tea group, oligofructose group, stigma maydis group and low, medium and high doses of compound formula groups were fed with high-fat diet. The treatment groups were given 6 test substances respectively by oral administration for 4 weeks, then, were intraperitoneally injected with Streptozocin to establish the model. And the test substances were continued until the end of the experiment. Glucose tolerance test was carried out at the beginning and the end of the experiment. Various indicators were measured after the experiment. Compared with the model control group, body weight, serum triglyceride, liver cholesterol, liver triglyceride, abdominal fat weight, organ coefficient and insulin resistance index in Pu'er tea group were reduced by 14.87%, 77.59%, 40.18%, 39.18%, 63.06%, 55.81% and79.88%, respectively, but had no significant effect on serum glucose and glucose tolerance. In the oligofructose group, the abdominal fat weight, organ coefficient, and the insulin resistance index decreased by 30.99%, 29.46% and 57.09%, respectively. In the stigma maydis group, only the liver triglyceride decreased by 36.06%.The compound formula significantly reduced body weight, body fat, serum lipids and hepatic lipid levels, and improved glucose and lipids dysmetabolism and insulin resistance effectively in STZ-induced diabetic rats.
