Abstract:
In this study, the effects of chickpea dietary fiber on blood lipid and antioxidant levels of hyperlipidemic rats were observed to provide a reference for the research of the health benefits of chickpeas. Forty male SD rats were fed with high-fat diet to establish hyperlipidemia model. Then the hyperlipidemia model of rats were randomly divided into hyperlipidemia model group, high chickpea fiber (30 g/kg high-fat diet), middle chickpea fiber (15 g/kg high-fat diet), and low chickpea fiber (5 g/kg high-fat diet) three intervention groups. The hyperlipidemia model group was fed with high-fat diet, and intervention groups were given high-fat diet containing different levels of chickpea dietary fiber. After 7 weeks of intervention, the animals were executed. The body weight, liver weight, epididymal fat weight, serum lipid levels and oxidative stress levels of rats were measured in each group. The results showed that: The weight gain, liver weight and epididymal lipid weight were decreased in chickpea dietary fiber group, compared with the hyperlipidemia model group. After five weeks the body weight was obviously decreased by 29.34%, the epididymal fat weight decreased 33.81%, 17.28% and 21.86% in the high, medium and low dose groups, respectively, but there was no significant difference in liver weight. In terms of blood lipids, triglyceride (TG) and low density lipoprotein (LDL-C) in high-dose group decreased by 51.52% and 40.45%, respectively. The total cholesterol (TC) value was optimal in the middle dose group, which was reduced by 34.31%. High density lipoprotein (HDL-C) in high-dose group increased by 42%. In terms of antioxidant capacity, the malondialdehyde (MDA) content in the middle-dose group was reduced by 40%, the total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) levels in the high-dose group were increased by 54% and 55%, respectively, the increases of T-SOD and GSH-Px levels were dose-dependent. It can be seen that the dietary fiber of chickpea can reduce body weight and regulate abnormal blood-lipids in hyperlipidemic rats, and this effect may be related to the improvement of antioxidation ability and reduction of oxidative stress injury in hyperlipidemic rats.
