The Improvement Effects of Ganoderma Lucidum Polysaccharide Formula on Fatigue and Immunodeficiency after Laparoscopic Surgery
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Abstract:
The effects of oral Ganoderma Lucidum polysaccharide formula on the immune recovery, fatigue improvement and sleep quality of patients after laparoscopic surgery were investigated in current study. A prospective, randomized, double - blind, placebo - controlled, single - center clinical trial method was adopted. Seventy - eight postoperative patients were randomly divided into a placebo group (n = 38) and a Ganoderma Lucidum group (n = 40), and were given placebo and Ganoderma Lucidum polysaccharide formula respectively for 30 consecutive days. The results were shown that in the Ganoderma Lucidum group, the total protein increased from 60.69 g·L-1 to 69.17 g·L-1, albumin increased from 33.47 g·L-1 to 41.27 g·L-1, and prealbumin increased from 196.31 mg·L-1 to 291.21 mg·L-1, all of which were significantly higher than those in the placebo group (P<0.05). Among immune cells, the percentage of CD3+ in the Ganoderma Lucidum group increased from 56.96% to 65.42%, the percentage of CD3+/CD4+ increased from 41.64% to 51.77%, the percentage of CD3+/CD8+ increased from 18.75% to 27.40%, IgA increased from 2.02 g·L-1 to 2.87 g·L-1, and IgG increased from 9.04 g·L-1 to 12.74 g·L-1, all significantly higher than those in the placebo group (P<0.05). The levels of TNF-α and IL-6 inflammatory factors in the Ganoderma Lucidum group were significantly decreased (P<0.05), the fatigue score decreased from 41.03 to 27.2, and the sleep quality index increased from 61.38 to 84.50, which were significantly better than those in the placebo group (P<0.05). In conclusion, Ganoderma Lucidum polysaccharide formula plays significant roles in nutritional support, immune regulation, anti-inflammation and anti-fatigue during the postoperative rehabilitation stage, and can effectively improve the overall recovery of postoperative patients, providing certain data support for the application of Ganoderma Lucidum polysaccharide formula.
