Research Progress on the Hypoglycemic Effect and Mechanism of the Components from Food and Medicinal Resources
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Abstract:
Recently, the incidence of diabetes mellitus has been increasing year by year, and the duration of western drug treatment is short though there are many adverse reactions. Therefore, the development of natural hypoglycemic ingredients with high efficiency and low toxicity has become a hot research field. In this paper, we reviewed the individual hypoglycemic effects of common active ingredients such as polysaccharides and saponins in natural food and drug resources, summarized their synergistic hypoglycemic effects with other hypoglycemic substances, and reviewed the hypoglycemic mechanisms of the components in food and drug resources in four aspects, namely, promotion of insulin secretion, enhancement of insulin sensitivity, improvement of glucose metabolism, inhibition of glucose absorption, and modulation of intestinal flora, to provide a basis for the development of hypoglycemic agents with biological activities. Much progress has been made in the development of hypoglycemic active ingredients, and in the future, the molecular mechanism of natural hypoglycemic ingredients can be explored in depth to discover more innovative therapeutic strategies, and to strengthen the clinical trials to verify their safety and efficacy in the human body.
