Anti-glycation Effects of Lumenato Extract Complex and Its Anti-aging Effects in Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The anti-glycation, antioxidant, and anti-aging effects of Lumenato extract complex were examined by establishing in vitro anti-glycation and antioxidant models and an in vivo model of aging in mice, respectively. The results revealed that the application of the extract complex at a concentration of 0.2 mg/mL resulted in inhibition rates of 44.39%, 19.22%, and 69.28% were for fructosamine, active carbonyl compounds, and fluorescent advanced glycation end-products, respectively. Furthermore, the anti-glycation effects of the complex were found to be superior to those of aminoguanidine, and the complex exhibited significant scavenging effects on O2-•, OH, and ABTS+• (in the order ABTS+•>•OH>O2-•). In addition, cell experiments revealed that the complex can significantly reduce the cytotoxicity of methylglyoxal and enhance the viability of HepG2 cells (P<0.05). In the mouse aging model, the complex alleviated the liver injury induced by D-galactose, as well as restored liver total superoxide dismutase levels (P<0.05). These findings thus provide evidence indicating that with respect to its anti-glycation, antioxidant, and anti-aging properties, Lumenato extract complex has promising application potential in the functional food and health product industries.
