Lychee Fermentation Products Enhance the Antioxidative Capacity of Human HaCaT Cells and Prevent Cell Apoptosis
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Abstract:
The effects of lychee fermentation products on ROS, SOD, hyaluronic acid, and aquaporin 3 (AQP3) production in human HaCaT cells as well as on the cell cycle and apoptosis were examined. In HaCaT cell models with hydrogen peroxide-induced oxidative damage, medium and high doses of lychee fermentation products suppressed the ROS production rate by more than 50%. All groups treated with lychee fermentation products showed significantly higher SOD activity levels, regardless of the treatment dose (P<0.05). The SOD activity level of the high-dose treatment group was 39.96% higher than that of the model group and comparable to that of the control group (P>0.05). In the HaCaT cell drying models, lychee fermentation products at all doses increased the expression levels of AQP3 and hyaluronic acid; specifically, the high-dose treatment group exhibited levels 2.08 and 1.11 times higher, respectively, compared to the model group. Furthermore, lychee fermentation products could regulate the progression of HaCaT cells from the G0/G1 phase to the S and G2/M phases (P<0.01) and significantly reduced the UVA irradiation-induced rate of cell apoptosis (P<0.05). Thus, lychee fermentation products can effectively enhance the antioxidative capability of HaCaT cells, promoting their division while preventing their apoptosis. These findings provide valuable reference data for research on the application of lychee fermentation products in the development of skin care products.
