Protective Effect of Plantain Extract against Acute Alcohol-induced Liver Injury in Mice
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Abstract:
In this study, the protective effect of plantain Extract (PE) against acute alcohol-induced liver injury was studied in mice. A mouse model of acute alcoholic liver injury was established by intragastric administration of 52% (by volume) edible alcohol. The liver index, serum alanine aminotransferase (ALT) activity, aspartate aminotransferase (AST) activity and triglyceride (TG) content, as well as superoxide dismutase (SOD) activity, catalase (CAT) activity, total glutathione (T-GSH) content, malondialdehyde (MDA) content of mouse liver tissues were determined, and pathologic observation of mouse liver tissues was performed. The results showed that compared with the model group, the liver index of the mice in the positive control group and the drug administration group decreased significantly (P<0.01), with the maximum decrease of 20.18% in the administered group, and the levels of serum ALT, AST and TG of the high-dose group were significantly reduced by 27.29%, 36.03% and 45.69%, respectively, and in the liver tissues, the CAT activity, SOD activity and T-GSH content increased significantly (by 16.36%, 18.42% and 28.66%, respectively), and the MDA content decreased significantly (by 36.89%). The histopathological analysis of the liver sections showed significant improvement in the degree of hepatic injury for the administered mice. Accordingly, PE has a significant protective effect against acute alcohol-induced liver injury.
