Antitumor Activity of a Polysaccharide-rich Medicinal and Food Complex
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Abstract:
The antitumor activity of a polysaccharide-rich Ganoderma lucidum complex water extract (hereinafter, PCW) was investigated. First, H22 tumor-bearing mouse models were established, including a control group, a model group, a positive control group (treated with lentinan (LEN)), and PCW groups (treated with low, medium, and high PCW doses). Then, the tumor inhibition rate, organ indexes, tumor and liver HE staining results, spleen lymphocyte proliferative ability, and serum cytokine levels were measured. The results showed that the tumor inhibition rates of the positive control group and low-, medium-, and high-dose PCW groups (50, 100, and 200 mg/kg) were 30.01%, 27.95%, 46.72%, and 54.23%, respectively. Low, medium, and high doses of PCW significantly improved the pathological changes of the spleen and thymus in H22 tumor-bearing mice (P<0.05). The growth of H22 liver cancer cells and PCW intervention did not have significant effects on the mouse liver. Compared with the spleen lymphocytes of the model group, those of the low-, medium- and highdose PCW groups exhibited significantly increased proliferative abilities (P<0.01). Medium and high doses of PCW significantly increased the IL-6, TNF-α, and IL-12 levels (P<0.05). In conclusion, PCW had a noticeable antitumor effect in H22 tumor-bearing mice. Therefore, the results of this study can provide new ideas for the development of antitumor products.
