Protective Effects of Oxygen-rich Water on Abnormal Blood Glucose Levels in Mice with Hyperglycemia and Hyperlipidemia
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Abstract:
The effects of oxygen-rich water on blood glucose and lipid levels in mouse models of hyperglycemia and hyperlipidemia were investigated. The hyperglycemia and hyperlipidemia models were constructed by feeding SPF adult male Kunming mice a high-sugar and high-fat diet and administering an intraperitoneal injection of alloxan. The models were separately treated with sterile drinking water, oxygen-rich water, and metformin for 30 days. During the intervention, the body weight, water intake, and food consumption were measured at regular intervals. The fasting blood glucose levels and oral glucose tolerance were measured before the mice were euthanized. In addition, the relevant organ and fat indices were calculated, and serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and lowdensity lipoprotein cholesterol (LDL-C) levels were determined. The liver glutathione (GSH) and malondialdehyde (MDA) contents and the superoxide dismutase (SOD) activity were determined. Furthermore, histopathological changes in the liver were observed. The results revealed that compared with the control model group, the experimental group treated with oxygen-rich water demonstrated significant reductions (P<0.05) in water intake, food intake, fasting blood glucose levels, and area under the oral glucose tolerance curve. In particular, the fasting blood glucose levels equaled 8.36 mmol/L, with a decrease of 31%, while the rest of the indicators did not change significantly (P>0.05). In conclusion, oxygen-rich water has an ameliorating effect on abnormal blood glucose levels of hyperglycemic and hyperlipidemic model mice; at the same time, it does not increase the oxidative stress levels in mice. The findings of this study provide new insights and references for adjunctive hypoglycemic strategies from the perspective of food.
