Zeaxanthin-enriched Olive Oil Delays Aging Induced by D-galactose in Mice
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Abstract:
The effects of olive oil rich zeaxanthin (OZT) on aging mice were investigated. Divide mice successfully modeled in subacute aging into model groups, OZT High, middle and low treatment group, olive oil group (OL) , vitamin E positive (VE) control group. After continuous gavage for 28 days, to analysis the effects of different doses of OZT on body weight, major organ index, serum levels of SOD, CAT, GSH-PX, ALT, AST and MDA, IL-2, IL-4, IL10 and IFN-γ in aging mice. The results showed that the body weight of model group was significantly different from that of CK (0) mice (P<0.01), and the body weight of high, middle and low dose mice were significantly different (P<0.05), After oral administration, the hypoxia tolerance time and swimming time of OL group mice were the shortest, while the high dose OZT group mice had the longest time, compared with VE group, there was no significant difference (P<0.05); OZT could also decrease the activities of ALT, AST, SOD, CAT and GSH-Px in serum of senescent mice,and enhanced the production of IL-2, IL-4 and IFN-γ, the effects of high-dose OZT was significantly better than that of OL and similar to that of VE. In conclusion, OZT has a good intervention effect on the subacute aging model induced by D-galactose, which can effectively improve the anti-oxidation ability of mice, prolong the anti-hypoxia time and improve the anti-fatigue effect, and delay the aging effect.
