Effects of Noni Fruit Polysaccharide on Bile Acid Metabolism and Gut Microbiota of Mice Fed on a High-fat Diet
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Abstract:
To investigate the preventive effect and potential mechanism of noni fruit polysaccharides (NP) on metabolic disorders and obesity induced by long-term intake of high-fat diet (HFD), an HFD mouse model and a pseudo germ-free (PGF) mouse model were established by providing high-fat feed and intragastric administration of broad-spectrum antibiotics, respectively. The effects of NP intervention on the body weight, fecal total bile acid (TBA) levels, and gut microbiota composition were analyzed and compared. Results showed that the body weight of mice in the NP group decreased by 11.91% and fecal TBA increased by 29.58% compared to mice in the HFD group. However, the beneficial effects of NP were not observed in PGF HFD mice, indicating that the gut microbiota plays a key role in inhibiting body weight gain and promoting fecal TBA excretion by NP in HFD mice. Results of Spearman correlation analysis suggest that Faecalibaculum, Dubosiella, and Muribaculaceae among others promoted TBA excretion and inhibited body weight gain in HFD mice at weeks 4 and 12. These findings indicate that NP can promote TBA excretion and inhibit body weight gain in HFD mice by enhancing the proliferation of the beneficial gut bacteria.
