Abstract:To study the protective effect of the Liver-protective and Sobering Soft Candy Mixture (LSSCM) against acute alcoholic liver injury in mice, a model of acute alcoholic liver injury was established, the liver index was calculated, and the changes in serum triglycerides (TG), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as well as the superoxide dismutase (SOD), malondialdehyde (MDA), alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in liver tissues, were measured. morphological changes were examined through pathological sections of liver tissues. The results showed that compared with the model group, the liver index, TG content and MDA content of the high-dose LSSCM group were significantly reduced by 12.33%, 48.35% and 39.10%, respectively; the levels of SOD, ALDH and ADH increased significantly by 18.61%, 44.59% and 124.61%, respectively; the levels of AST and ALT were significantly reduced by 32.26% and 40.71%, respectively. The results of mouse liver histopathological sections showed that the damaged livers of mice in each dose group of LSSCM were improved to different degrees. In summary, LSSCM had a significant ameliorating effect on hepatomegaly, lipid metabolism disorders, and hepatic oxidative stress caused by alcohol-induced acute liver injury in mice, and could effectively prevent and ameliorate acute alcoholic liver injury.