Structural Lipid Rich in OPO, OPL and LPL Promotes Lipid Metabolism in C57BL/6 Mice
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Abstract:
In this study, a structured lipid (SL) rich in OPO (1,3-dioleic acid-2-palmitic acid triglyceride), OPL (1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride) and LPL (1,3-dilinoleic acid-2-palmitic triglyceride) was enzymatically synthesized, and the effect of the SL on lipid metabolism in mice was investigated. Twenty-one healthy C57BL/6J experimental mice were selected and divided into 3 groups: a fat-free homozygous diet, with the same dose of soybean oil, InFat CC (an OPO-rich product) or SL (rich in OPO, OPL, and LPL) by gavage. During the feeding period, changes in body weight and food intake were measured, and the related lipid indicators in the serum and liver of the mice were determined. The experimental results showed that the average body weight (24.97 g) of the mice fed with SL was lower than that of the mice in the soybean oil (27.29 g) and InFat CC (26.54 g) groups. The levels of total cholesterol (TC, 0.05 mmol/g protein), total triglyceride (TG, 0.14 mmol/g protein), and fatty acid synthase (FAS) mass fraction (0.13 mg/g liver) in the liver of mice from the SL group were significantly lower than those in the soybean oil group and InFat CC group (P<0.05). The study suggests that SL can control weight gain in mice by promoting hepatic lipid metabolism, thus provids a theoretical basis for the dietary application of structured lipids.
