Anti-inflammatory and Antioxidant Effects of Ruanerli
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Abstract:
Ruanerli is a characteristic fruit of Gansu and has the function of moistening the lungs and relieving cough, though the underlying mechanism is rarely studied. Inflammation is the main cause of respiratory diseases. The anti-inflammatory and antioxidant effects of Ruanerli through in vitro and in vivo experiments were evaluated, thereby providing a theoretical basis for its application in respiratory diseases. The anti-inflammatory effects of Ruanerli were evaluated by the mouse ear swelling test based on the organ index, number of white blood cells and inhibition rate of ear swelling. The rat foot swelling test was used to examine the antioxidant effect of Ruanerli using the activities of antioxidant enzyme, serum MDA content and PGE2 level as the indices. Through in vitro free radical scavenging tests , using the four-parameter fitting method, the scavenging abilities of Ruanerli against hydroxyl radical (OH•), superoxide anion radical (O2-•) and DPPH radical were evaluated. The results showed that Ruanerli could significantly suppress the ear swelling caused by xylene in mice (the inhibition rate of the high dose group reached 36.16%), reduce the organ index and reduce the total amount of white blood cells, neutrophils, monocytes and lymphocytesin peripheral blood. Ruanerli could significantly reduce the contents of serum PGE2 and serum MDA while enhancing the activities of serum SOD, CAT and GSH-Px in rats with egg white-induced inflammation. Within the analysed concentration range, Ruanerli showed strong scavenging power against DPPH, OH- and O2- free radicals, with the IC50 values being 0.26 g/mL, 0.23 g/mL and 0.27 g/mL, respectively. Therefore, Ruanerli pear has good anti-inflammatory and antioxidant effects, and the underlying mechanisms may be related to the reduced production of inflammatory factors, increased free radical scavenging abilities, and enhanced activities of antioxidant enzymes.
