Research Progress on the Metabolic Network of Cordycepin in Cordyceps militaris and Its Key Nodes
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Abstract:
Cordycepin is one of the core high-value-added secondary metabolites produced by fungi belonging to the genus Cordyceps. Compared with other industrial strains, Cordyceps militaris benefits from the innate metabolic flux in the synthesis of adenosine analogs such as cordycepin. In recent years, with the development of omic analysis technology and Cordyceps militaris gene-editing technology, the metabolic network of cordycepin synthesis, particularly the key substrate synthesis pathway, has been completely analyzed. Therefore, this review, the known metabolic network of cordycepin is modularized, dividing it into the central carbon metabolic pathway, inosinate (IMP) pathway, and substrate biosynthesis pathway, completely describing its metabolic network. The composition of cordycepin precursor and the influence of multiple dispersion pathways and key nodes on the synthesis of cordycepin have been analyzed, and the synthesis and flow direction of IMP substances have been systematically elaborated. This shows that the synthesis and metabolism of IMP is the essential node in cordycepin synthesis. These discoveries provide a comprehensive foundation for optimizing the metabolism network of Cordyceps militaris through metabolic engineering and synthetic biology strategies, for developing a stable and high-yielding Cordyceps militaris strain in the future.
