Comparison of Sleep Improvement Effects of Three Common Functional Formulations
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Abstract:
Sleep improvement effect of Semen Ziziphi Spinosae extract, longan aril extract, and γ-aminobutyric acid. were compared through direct sleep, sodium pentobarbital-induced sleep extension, subthreshold dose sodium pentobarbital-induced hypnosis, and sodium barbital-induced sleep latency experiments were carried out. The results showed that all three functional formulations had no significant effect on the direct sleep and body weight of mice. However, the high (33.3 mg/kg•d), medium (16.7 mg/kg•d), and low dose (8.3 mg/kg•d) of γ-aminobutyric acid, the high (110 mg/kg•d) and medium (55 mg/kg•d dose of Semen Ziziphi Spinosae extract, as well as the low dose (66.5 mg/kg•d) of longan aril extract could significantly prolong the sodium pentobarbital-induced sleep time of mice. Further, γ-aminobutyric acid had the greatest hypnotic effect on mice treated with the subthreshold dose of sodium pentobarbital. Among the 12 mice tested, 2 fell asleep at high, medium, and low doses of γ-aminobutyric acid. Thus, the incidence of sleep reached 16.67%. The high, medium, and low dose of Semen Ziziphi Spinosae extract could shorten the sleep latency of mice hypnotized by sodium barbital, whereas only the high- and medium-dose groups were significantly different from the control group (P<0.05).
