Abstract:A mixed acid system-quadrupole collision reaction cell-ICP/MS (Inductively Coupled Plasma Mass Spectrometry, ICP/MS) method for determination of lead and arsenic in silicion-containing food additives was set up. Samples were pretreated by microwave digestion with a mixed hydrofluoric acid-hydrochloric acid-nitric acid system, then the lead and arsenic were simultaneously determined by the quadruple collision cell-ICP/MS method, with Pb208 and As75 as the target elements for determination, Bi209 and Ge72 as the corresponding internal standard elements, and the collision/reaction cell technology and helium kinetic energy discrimination (KED) mode for analysis and detection. Lead and arsenic had a good linear relationship in the range of 0.000 5~0.100 0 μg/mL with r2 greater than 0.999. The samples were subjected to standard addition recoveries experiments, and the spiked recoveries of lead and arsenic were 92.0%~107.0% and 94.0%~104.0%, respectively. The samples were spiked and recovered to verify that the recoveries of lead and arsenic were 2.49% and 1.68%, respectively. The detection limits of lead and arsenic were 0.003 mg/kg and 0.002 mg/kg, respectively. This method had advantages in terms of high accuracy, high sensitivity, high precision and little interference, which is suitable for the determination of lead and arsenic in silicon-containing food additives, as well as quality monitoring and safety evaluation of silicon-containing food additives.
