The Functional Dyspepsia-ameliorating Effect of Phyllanthus emblica L. Extract and Its Formulated Productss in Mice
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Abstract:
The ameliorating effects of Phyllanthus emblica L. extract and the five formulated products of Phyllanthus emblica L., hawthorn and poriacocos on functional dyspepsia were investigated to provide a theoretical basis for improving functional dyspepsia. A functional dyspepsia mice model was established, and mice were randomly divided into a modelgroup, control group, Phyllanthus emblica L. extract treated groups (low dose, medium dose and high dose), and five kinds of formulated product treated groups. Phyllanthus emblica L. extracts (low, medium and high dose) and Phyllanthus emblica L., hawthorn and poriacocos formulated productswere orally administered for three consecutive weeks. The results showed that, medium-dose (150 mg/kg) and high-dose (300 mg/kg) of Phyllanthus emblica L. extract and its formulated products could increase the body weight and feed intake of mice after modeling; the gastricemptying rate and small intestinal propulsion rate increased, i.e. by 45.16% and 58.43%, respectively, in the high-dose treatment group compared with the model group (P<0.05); The pepsin activity increased, i.e. by 39.33% in the medium-dose treatment group compared with the model group (P<0.01); the serum motilin and gastrin levels increased significantly, especially in the high-dose treatment group (increased by 149.89% and 86.06%, respectively, P<0.01);the active serum intestinal peptide level decreased, especially the effect of formulated product treatment group decreased significantly (by 34.12%; P<0.05). The ameliorating effect of Phyllanthus emblica L. extract and its formulated products against functional dyspepsia were confirmed in mice. The results of this study provide new ideas for the development of health products to promote gastrointestinal function and lay a foundation for subsequent product development.
