Regulatory Effects of Buckwheat Quercetin on Lipid Metabolism and Adipokines in Rats Receiving A High-fat Diet
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Abstract:
To examine the effects of buckwheat quercetin on lipid metabolism and adipokines in rats receiving a high-fat diet, 54 SD rats were randomly divided into a control group; a model group; a positive group; and groups receiving low (50 mg/kg), moderate (100 mg/kg), and high (200 mg/kg) doses of buckwheat quercetin (QUE). Five weeks after establishing a hyperlipidemic rat model, buckwheat quercetin was administered to the rats as intervention. Serum and liver lipid levels as well as serum antioxidant and adipokine levels of rats in each group were measured, and histopathological sections of their livers were examined. Compared with those in the model group, serum and liver TC and TG levels were significantly reduced in groups receiving QUE; specifically, the high-dose QUE group experienced a 33.47% and 28.66% decrease in serum TC and TG levels, respectively, indicating significant differences compared with values in the model group (P<0.01). Moreover, the high-dose QUE group experienced a 12.3% decrease in chemerin levels, 19.83% decrease in CMKLR1 levels, 15.87% decrease in TLR4 levels, and 14.12% decrease in NF-κB levels; simultaneously, however, serum GSH-Px activity was increased by 33.87 U/mL, which was extremely significant (P<0.01), whereas serum CHE activity was decreased by 79.56 U/mL in the high-dose QUE group. Thus, buckwheat quercetin closely regulated dyslipidemia in rats receiving a high-fat diet, reduced the levels of chemerin and its receptors CMKLR1 and TLR4, inhibited the activation of the NF-κB pathway, suppressed the accumulation of cholesterol, and regulated the metabolism of lipids and levels of adipokines.
