Dual Inhibitory Effects of Chinese Olive (Canarium album L.) Extract on Renin and Angiotensin-converting Enzyme
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Abstract:
In this study, the inhibitory effects of the olive extracts obtained by different solventson the key enzymes, renin and angiotensin-converting enzyme (ACE), in the renin-angiotensin system were investigated. At the same time, the antioxidant capacity and the contents of total phenols and total flavonoids were analyzed. The results showed that the activity of the organic solvent extract was generally higher than that of the water extract. At the concentration of 0.50 μg/μL, the methanol extract had the highest renin inhibitory activity (95.89%). At the concentration of 0.29 μg/μL, the acetone extract had the highest ACE inhibitory activity (92.71%), and the strongest antioxidant activities, possessing the ABTS+ free radical scavenging ability of 384.86 mg TE/g DW, DPPH free radical scavenging ability of 309.23 mg TE/g DW, and iron ion reducing ability of 479.40 mg TE/g DW. Meanwhile, the contents of total phenols and total flavonoids in the acetone extract were the highest (318.14 mg GAE/g DW and 45.46 mg CE/g DW, respectively). Further correlation analysis showed that total phenols were significantly associated with renin and ACE inhibitory activities (P <0.05). This study found that olive extract showed excellent renin and ACE inhibitory activities, and the activity of organic solvent extract was superior to that of water extract. These results provide a new idea for the study of new blood pressure regulators and a theoretical basis for the scientific and sustainable development of olive resources.
