Anti-exercise-fatigue Effect of Acanthopanax senticosus Polysaccharide Based on Oxidative Stress
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Abstract:
The anti-exercise-fatigue and oxidative stress inhibitory effects of Acanthopanax senticosus polysaccharide (ASP) was investigated. Mice were randomly divided into the control group and the low-, medium- and high dose ASP groups (50, 100 and 200 mg/kg), and the intervention lasted for 28 days. The results showed that compared with the control group, the weight-bearing swimming times of mice for the low-, medium- and high dose ASP groups were prolonged by 13.79%, 33.68% and 48.89%, respectively, the contents of muscle glycogen and liver glycogen increased, and the contents of BUN, lactic acid, blood glucose and blood ammonia decreased; Compared with the control group, the activity of GSH-Px in the skeletal muscle for the low-, medium- and high dose ASP mice increased by 29.82%, 53.03% and 59.32%, respectively, their SOD activities increased by 9.64%, 15.23% and 50.05%, respectively, and their MDA contents decreased by 16.45%, 36.76% and 45.82%, respectively; Compared with the control group, NOX2 gene expression in the skeletal muscle of the medium- and high dose ASP groups and the NOX4 and Keap1 gene expressions of the low-, medium- and high dose ASP groups decreased, whilst Nrf2 and HO-1 gene expressions of all the ASP groups increased, and the expression levels of related proteins showed a consistent trend. The results showed that ASP has an anti-exercise-fatigue effect in mice, which is related to the inhibition of NOX2 and NOX4 expressions and the regulation of Nrf2/ARE signaling pathway, thereby inhibiting oxidative stress.
