Improving Glycolipid Metabolism and Oxidative Stress in Type Ⅱ Diabetic Mice via Leaf Ethanolic Extracts of Lithocarpus polystachyus Rehd.
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Abstract:
The improvement effects of leaf extracts of Lithocarpus polystachyus Rehd. on glycolipid metabolism and reduce oxidative stress in mice with Type Ⅱ diabetes was examined. Type Ⅱ diabetes mellitus (T2DM) mice were divided into the following groups: blank control group, model control group, positive control group, LEL high and low-dose (30, 15 g/kg) groups, and mice of each group were continuously administered the corresponding drugs for 4 weeks. During the experiment, coat color, mental state, body weight, and fasting blood glucose (FBG) levels of the mice were measured. After the experiment, the mice were tested for oral glucose tolerance and serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels. Histopathological examination of liver tissue was conducted at the end of the experiment and glycogen, superoxide dismutase (SOD), reduced glutathione (GSH), and malondialdehyde (MDA) levels were measured. The results showed that LEL could improve the mental state and polyuria of T2DM mice. Compared with the model control group, the fasting blood glucose in low- and high-dose LEL groups decreased by 45.38% and 46.25% respectively, and the serum levels of OGTT, TG, TC, and LDL-C in were also significantly reduced, whereas the HDL-C level was significantly increased (P<0.01). Liver glycogen content and SOD and GSH activities in liver tissue were significantly high, whereas the MDA content was significantly low (P<0.01), and the steatosis and inflammatory cell infiltration in T2DM were significantly alleviated after administering LEL for 4 weeks. The results indicate that LEL can significantly reduce blood glucose, increase liver glycogen content, improve lipid metabolism, and reduce oxidative stress damage in T2DM mice.
