β-Cyclodextrin Encapsulated Pogostemon cablin Oil with the Assistance of Static Magnetic Field
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Abstract:
In order to explore the effect of static magnetic field on the embedding performance of volatile drugs, the β-cyclodextrin and the Pogostemoncablin oil were used as embedded wall material and core material. The embedding rate of β-cyclodextrin and Pogostemoncablin oil under different binding parameters were analyzed at 0, 3, 6 and 10 mT static magnetic field. The results showed that the embedding rate of Pogostemoncablin oil increased firstly and then decreased with the increase of wall material mass fraction, core material mass fraction, wall core ratio, temperature, treatment time and rotational speed. Under the same inclusion conditions, compared with the control, the embedding rate of Pogostemoncablin oil increased significantly with the increase of static magnetic field intensity (P<0.05). Compared with the control, under 3, 6 and 10 mT static magnetic field, the embedding rate of Pogostemoncablin oil increased by 4.46%, 8.80% and 13.01% respectively when wall material of β- cyclodextrin with a mass fraction of 30% and the core material of Pogostemoncablin oil with a mass fraction of 80% were treated at 45 ℃ and 200 r/min for 2 h with a wall core ratio of 3:1. Static magnetic field enhanced the entrapment performance of the Pogostemoncablin oil inclusion compound, and this study provides a new reference method for promoting the embedding of volatile drugs.
