In Vivo Anti-aging Effect of Red Slate Cod Croaker Isinglass on Caenorhabditis elegans
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Abstract:
In this experiment, Caenorhabditis elegans was used as a model, and red slate cod croaker isinglass was used as the raw material. The effects of red slate cod croaker isinglass (HMYJ), ready-to-eat croaker gelatin (JSYJ) and their compound product (YJFP) on the life span, exercise capacity, stress capacity and antioxidant activity of Caenorhabditis elegan. The results showed that HMY-J, JSYJ and YJFP prolong the life span of nematodes by 9.09%, 9.09% and 27.03%, respectively, compared with the blank control group. JSYJ and YJFP could promote nematode’s motility. HMYJ, JSYJ and YJFP could resist the damage of ultraviolet stress and heat stress. Under ultraviolet stress, YJFP, JSYJ and HMYJ increased the survival rate of nematodes by 33.33%, 22.22% and 11.11%, respectively. YJFP, JSYJ and HMYJ increased the survival rate of nematodes by 11.11% under heat stress. In addition, after HMYJ, JSYJ and YJFP intervention, the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased significantly (P<0.05), and the content of malondialdehyde (MDA) decreased significantly (P<0.05), with the JSYJ group decreasing by 43.20%, the HMYJ group decreasing by 30.80%, YJFP sample decreasing by 22.80%. In conclusion, HMYJ, JSYJ and YJFP can prolong the life span of nematodes, improve their locomotion ability, improve the abilities of nematodes to resist stress injury and the in vivo activities of antioxidant enzymes to slow down the aging of nematodes. This study also provides a theoretical basis for the development and utilization of Isinglass.
