The Immune-enhancing Effect of Drug-food Homologous Prescription Combined with Probiotics on Immunocompromised Mice
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The aim of this study was to investigate the regulatory effect of the combination of drug-food homologous prescription and probiotics on the immune function of immunocompromised mice induced by cyclophosphamide (CTX). Except for the control group gavaged with normal saline, the mice in the other groups were intraperitoneally injected with CTX (100 mg/kg bw, for 4 days). Mice with similar body weights were randomly divided into 6 groups: control group, immunosuppression (model) group, drug-food homologous group III, drug-food homologous improvement group (IV), probiotics group (V), and IV-V combination group (VI). After the administration for 14 days, the effects of III, IV, V and VI on the thymus and spleen indices, phagocytic ability, spleen lymphocyte proliferation, NK cell activity and the levels of the formed IgG, IgA and IgM in immunodepressed mice were assessed. The results showed that the thymus index (1.46, 1.67, 1.50 and 1.92 g/kg) and spleen index (2.32, 2.54, 2.52 and 2.82 g/kg), phagocytic ability (1.39, 1.45, 1.42 and 1.43), spleen lymphocyte proliferation (1.39, 1.45, 1.42 and 1.43) and NK cells activity (0.35, 0.43, 0.36 and 0.71) were enhanced significantly (P<0.05) in the group III, IV, V and VI. IV, V and VI all significantly increased the levels of IgG (224.21, 163.21 and 253.35 mg/L), Ig A (34.86, 22.09 and 41.17 mg/L), and IgM (84.01, 78.23 and 100.28 mg/L) (P<0.05). These results suggested that the combination of the modified drug-food homologous prescription and probiotics could enhanced significantly the immune function of the CTX-immunosuppressed mice.
