Development and Efficacy Evaluation of a Red Ginseng-Bird's Nest-Jujube Seed Compound Sleep Aid Drink
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Abstract:
In the currently study, the optimal formula of a "red ginseng-bird's nest-jujube seed compound sleep aid drink" was developed using red ginseng, bird's nest and cooked sour jujube seeds as the main raw materials. The effect of the compound drink on sleep improvement was determined in the Balb-c male mice subjected to 30-day continuous oral gavage of the compound drink by the direct sleep test, prolonged pentobarbital sodium sleep time test, pentobarbital sodium subthreshold dose hypnotic test, and barbital sodium sleep latency test. The related indicators of mouse’s brain tissues were measured. With the results showed that red ginseng-bird's nest-jujube seed compound sleep aid drink at low, medium and high doses could prolong sleep time of the mice under the action of pentobarbital sodium by 24.72%, 66.11%, and 85.12%, respectively. The compound drink at the medium and high doses could also increase the sleep-onset rate to 80% in the mice treated with pentobarbital sodium at the subthreshold dose, while shortening effectively the sleep latency for the mice barbital sodium hypnosis. In addition, compared with the blank group, the 5-HT contents of the treatment groups increased significantly (increased by 398.28, 742.34, and 830.08 ng/mL for the low, medium and high dosage groups, respectively). The TPH contents of the medium and high dosage groups increased significantly (increased by 433.82 and 663.74 pg/, respectively). The GABA contents in the brain tissues of the mice in the medium and high dosage groups increased significantly (increased by 0.04 and 0.06 µmol/L, respectively), while the Glu contents of these two groups of mice also increased significantly (increased by 0.20 and 0.50 µmol/L, respectively). In summary, the red ginseng-bird's nest- jujube seed compound sleep aid drink can improve sleep, and such an effect is related to the regulation of the serotonin system and neurotransmitters in the brain tissue.
