Immune-regulatory Functions and Safety of Chewable Ginseng-Fritillary Bulb Tablet
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Abstract:
In this study, the immune-regulatory functions and safety of chewable Ginseng-Fritillary bulb tablets were evaluated in vivo. For the immune-regulatory function evaluation, Kunming mice were administered chewable Ginseng-Fritillary bulb tablets by oral gavage at daily doses of 1.20, 0.80, and 0.40 g/kg (measured by body weight of mouse) for 30 days, and then body weight, organ/body weight ratio, cellular immunity, humoral immunity, monocyte-macrophage function and NK cell activity were measured. To assess the safety of the tablets, the acute toxicity, genotoxicity (via the Ames test, the bone marrow micronucleus test and the mouse sperm malformation test), and the 30-day feeding test were performed by using SD rats under a dose of 20.00 g/kg. The results show that the chewable Ginseng-Fritillary bulb tablets at all tested doses have no significant effects on the body weight and the lymphoid organ/body weight ratio of mice. In the high-dose group (1.20 g/kg), the tablets could significantly induce the delayed-type hypersensitivity (DTH) in mice and increase the number of antibody-producing cells, the macrophage phagocytosis index (7.04), and the serum hemolysin level (p<0.5). Furthermore, the safety evaluation results suggest that the tablets have no significant effects on the body weight, food intake, food utilization rate, hematological indices, blood biochemical indices and organ coefficients of mice. In addition, under the tested doses, no significant mutation or abnormality in the micronucleus formation of bone marrow cells and sperm cells were observed. In conclusion, the chewable Ginseng-Fritillary bulb tablets can enhance immunity reasonably safely.
