In Vitro Antioxidant and Anticancer Properties of Dehydroepiandrosterone from Sweet Potato
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Abstract:
In this study, sweet potato was selected as the raw material, dehydroepiandrosterone (DHEA) was prepared by Aspergillus oryzae fermentation. The in vitro antioxidant, anti-aging, hypoglycemic and anticancer effects of the DHEA extract from the fermented sweet potato before and after purification were examined. The results showed that the retention time was 11.21 min and the peak area was accounted for 76.44% when the sweet potato DHEA extract was purified by silica gel adsorption. With the increase of concentration, the scavenging abilities for DPPH, ABTS and hydroxyl radicals and the total reducing ability of the DHEA extract before and after purification increased significantly (p<0.05), and reached the maximum at 0.10 mg/mL. The α-amylase activity inhibitory rates of the purified DHEA extract ranged from 2.16% to 55.54%, and reached the maximum at 0.80 mg/mL. The tyrosinase activity inhibitory rates of the purified DHEA extract were in the range of 5.55%~50.57%, and reached the maximum at 0.10 mg/mL. The purified DHEA extract only exhibited a significant inhibitory effect against the breast cancer cell MCF-7 at a concentration of 2.30 mmol/L (p<0.05), with the inhibition rate being 47.50%. But the purified DHEA extract had insignificant effects against lung cancer cell A549 and cervical cancer cell Hela (p>0.05). This study provides a reference for the development of functional foods using sweet potato DHEA, which is conducive to the development of sweet potato natural products.
