Assessment of Acute Toxicity of Nothopanax delavayi (Franch.) Harms ex Diels Water Extract
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Abstract:
Leaves of Nothopanaxdelavayi (Franch.) Harms ex Diels (LWC), was used as raw material, the acute toxicity and half lethal dose (LD50) of its water extract was investigated. Results showed that the oral LD50 of LWC water extract was higher than 15000 mg/kg.bw, which is actually non-toxic substance. Comparing to control group, gavage of 2521~15000 mg/kg•bw LWC water extract had no significant effect on the weight gain of both female and male mice (p>0.05), showing insignificant influence on organ coefficients of heart, spleen and lung, serum ALT, AST and creatinine level of female mice (p>0.05), neither were lung and kidney organ coefficients, serum ALT of male mice (p>0.05). The serum urea level of female (dose ≥7350 mg/kg•bw) and male (dose ≥5145 mg/kg•bw) mice was significantly higher than that of the blank control group (p<0.05), indicating that the very high dose of LWC tea water extract had a certain toxicity to the kidney. In summary, acute toxicity studies have shown that the oral LD50 of LWC water extract is more than 15000 mg/kg•bw, which is a practically non-toxic substance, however it is toxic to the kidneys at extremely high doses.
