Comparative Analysis of Effects of Whole Egg and Substitute of Egg Yolk Consumption on Lipid Metabolism in Mice with Metabolic Syndrome
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Abstract:
In order to study the effects of whole egg and substitute of egg yolk consumption on lipid metabolism in mice with metabolic syndrome (MetS), a MetS mouse model was constructed through high-fat feeding in this experiment. Forty C57BL/6 male mice were divided into control group (normal diet, ND), model group (high-fat diet, HFD), whole egg consumption group (high-fat diet+egg, EGG), substitute of egg yolk consumption group (high-fat diet+substitute of free egg yolk, SUB) and lovastatin group (Lov). The organ index, biochemical indexes, tissue sections and enzyme levels were measured at the end of the experiment (60 d). The results showed that the weight gain was significantly reduced by the intake of EGG (p<0.05). The levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in EGG serum were significantly reduced by 74.51%and 77.03%, respectively, than HFD. The increase of superoxide dismutase (SOD) and malondialdehyde (MDA) enzyme activities in the liver caused by HFD were inhibited by EGG and SUB (p<0.05). SOD and MDA in the liver of the EGG group were significantly lower than those of the HFD (p<0.05) by 24.90% and 60.10%, respectively. The TC and serum triglyceride (TG) in the liver of the SUB group were the lowest, which were 0.11 mmol/L and 0.42 mmol/L, respectively. EGG significantly reduced the AST and AST/ALT ratios in serum and liver. The AST and AST/ALT ratios in liver of the EGG group were 44.99% and 81.74% of the HFD group, respectively. In addition, EGG can significantly inhibit the formation of lipolytic vacuoles in liver tissues and inhibit the enlargement of epididymal fat cells. Therefore, EGG can better regulate the lipid metabolism of MetS mice compared with SUB.
