Research Progress on the Surface Microorganisms of Citri Reticulatae Pericarpium and Derived Microbial Transformation of Flavonoids
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Abstract:
Citri reticulatae pericarpium is a traditional Chinese herbal medicine, which can be used as both medicine and food. It has functions related to the regulation of Qi and spleen strengthening, drying dampness and phlegm reduction. It is rich in flavonoids, volatile oils, alkaloids, limonoids and other trace elements. The flavonoids are the main active components, which exhibit a variety of pharmacological activities, including anti-inflammatory, anti-oxidant, anti-thrombotic, anti-bacterial, anti-viral, hypoglycemic and hypolipidemic effects. It has been widely used in many fields, such as food and healthcare products. However, the applications of flavonoids have been restricted due to their poor solubility and low bioavailability. With the continuous development of biotechnology, microbial transformation of flavonoids and other active substances has become a research hotspot domestically and abroad. It has been reported that the structural characteristics, biological activities of the active components of citri reticulatae pericarpium, as well as its microorganisms and their transformed flavonoids have been deeply and systematically studied. This article reviews the research progress of the microorganisms on the surface of citri reticulatae pericarpium, and their roles in the biotransformation of flavonoids, which provides a reference for the development and application of microbial transformation of active flavonoids from citri reticulatae pericarpium.
