Hypoglycemic and Lipid Lowering Effects of Potato Resistant Starch on Hyperlipidemia Rats
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Abstract:
To explore the hypoglycemic and blood lipid-lowering effects of potato resistant starch on hyperlipidemia rats, 48 rats were randomly divided into a blank control group and a model control group according to their body weights. After 2 weeks of high-fat feeding, they were randomly divided into 5 groups according to the total cholesterol (TC) level: high-fat model group, positive control group, and potato resistant starch high-, medium-, and low-dose groups. After 6 weeks of intervention, the body weights, liver coefficients, blood lipid levels and other indicators of the rats in each group were measured, and the pathological tissue sections of their livers were examined. Results: Compared with the blank group, the body weight of the high-fat group increased by 2.21%, the heart weight, liver weight, liver coefficient, and periepididymal fat weight all increased by 23.70%, 85.84%, 63.88% and 23.74%, respectively; TC, TG, LDL-C and blood sugar levels increased; The high-fat model was successfully established. Compared with the high-fat group, the experimental group's body weight, liver weight, liver coefficient, and periepididymal fat weight decreased, with the largest reductions being 2.50%, 14.18%, 9.18%, and 19.46%, respectively; The levels of TC, TG, LDL-C, AI and blood sugar were significantly reduced, and the largest reductions were 29.84%, 49.33%, 59.21%, 43.89% and 11.33%, respectively, with no significant difference found in HDL-C. The results of HE staining experiments showed that compared with the high-fat group, the degrees of liver steatosis in the rats of the high- and medium-dose groups were significantly improved. The results showed that potato resistant starch can lower the blood sugar and blood lipid levels, and makes a positive contribution to the prevention and treatment of hyperlipidemia.
