Compound Tea Lowers Lipid Levels by Promoting Organic Acid Metabolism
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The lipid-lowering effects of compound tea were investigated to determine the mechanism underlying its action and provide theoretical support for the development and application of this compound tea. Specific pathogen-free male Kunming mice were randomly divided into four groups: a model control group (NK), positive control group (YK), blank control group (CK), and compound tea treatment group (DH), with 10 mice in each group. After 30 days of intragastric administration of compound tea, the body weight, liver coefficient, liver morphology, and liver metabolism of organic acids were analyzed in mice with hyperlipidemia. The weight of mice in the NK group was significantly increased compared to that of the mice in the CK group, whereas the weight gain and liver-to-body ratio of mice in the DH group exhibited no significant difference. Fifty-two differential organic acid metabolites were detected. Compared to the CK group, b-ureaisobutyric acid and n-acetyl-aspartyl-glutamate in the DH group were significantly upregulated, whereas creatine and 14 other organic acids were significantly downregulated. In the YK group, 13 organic acids, including argininosuccinic acid, were upregulated, whereas 17 organic acids, including chlorogenic acid, were downregulated. Compound tea had a better ability to regulate blood lipids compared with the YK (positive control, Xuezhikang). This may be because compound tea can regulate the metabolism of organic acids, such as chlorogenic acid, and their associated metabolic pathways, as well as ameliorate dyslipidemia induced by a high-fat diet in mice, thereby reducing body weight and blood lipid levels.
