Relationship between Molecular Structural Differences and Controlled-releasing Properties of Chitosan-based Hydrogel
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Abstract:
To delivery bioactive compound with good bioavailability, crosslinked chitosan (CS) hydrogel with different microstructure and its controlled-releasing property were investigated. These hydrogel particles were crosslinked by tripolyphosphate (TPP) or sodium hexametaphosphate (SHMP) and analyzed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and thermal gravimetric analysis (TGA). SHMP-crosslinked CS hydrogels showeda stronger peak near 1530 cm-1, which presented the interaction between CS and anionic crosslinkers and related to more binding sites of the crosslinker. From the result of TGA, after crosslinking, the thermal stability of this hydrogel was increased by phosphate group of crosslinker enhancing the intramolecular hydrogen bond force among CS molecules. Moreover, the swelling behavior and controlled-releasing property of these materials were also tested. TPP-crosslinked CS hydrogel had better swelling capacity than SHMP-crosslinked one, but the in vitro releasing study revealed that the total cumulative release percentage of bovinsersum albumin from SHMP-crosslinked CS hydrogel particle (30.47~50.27%) was lower than those by TPP (59.90~76.57%) because of the reduction of crosslinking strength in acidic environment and compact network structure formed later. With the changes of crosslink processing, the molecular structure of crosslinked chitosan hydrogel was varied, which influnced itsswelling ability and controlled-releasing property. The results of this study can provide some reference for the selection of chitosan carrier materials, sustained release and improving the bioavailability of active protein functional factors.
