In-vivo Anti-tumor Effects of the Proteins of Apriona swainsoni Larvae on 4T1 Tumor-bearing Mice
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Abstract:
4T1 tumor-bearing mice models were established to examine the in-vivo anti-tumor effects of proteins extracted from Apriona swainsoni larvae. Changes in the body weight and tumor growth of the mice treated with different protein concentrations were observed during the experiments. The growth of the 4T1 tumor cells was detected by bioluminescence imaging. All mice were sacrificed after treatment administration, and the tumor inhibition rate and indexes of main organs were subsequently calculated. Compared with the tumor model control group, the tumor-bearing mice treated with different concentrations of proteins of Apriona swainsoni larvae showed no significant changes in their body weights or the weights and indexes of main organs, whereas the tumor weights significantly reduce (p<0.05). The tumor inhibition rates in the groups treated with the Apriona swainsoni larval protein at low, medium, and high doses were 23.08%, 36.06%, and 21.63%, respectively. The fluorescence signals of the 4T1 tumor cells in these three treatment groups were attenuated in comparison with those of the control group. The result was consistent with the tumor growth observations. It was preliminarily concluded that the proteins of Apriona swainsoni larvae have certain in-vivo anti-tumor effects, and they have no obvious toxic and side effects on the body and the main organs of the 4T1 tumor-bearing mice.
