Protective Effect of Jie-Gan Tablets on Alcoholic-induced Acute Liver Injury in Mice
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Abstract:
The protective effect of Jie-Gan tablets (JGT) on acute alcohol liver injury mice was explored. A mouse model of acute alcoholic liver injury was established by one-time intragastric gavage (i.g) with 50% alcohol. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglyceride (TG), and the content of malondialdehyde (MDA) and activity of glutathione peroxidase (GSH-Px) in the liver tissue homogenate of mice were determined. The morphological changes of tissue sections were analyzed by H&E staining, and the hepatoprotective effect of JGT was evaluated. The results showed that the increases of the two serum transaminase levels in mice were significantly inhibited by the pretreatments with different doses of JGT and bifendatatum (p<0.05), and the highest inhibition rate up to 61.81%. The serum TG level was significantly reduced in the JGT high-dose group (p<0.05), with a decrease of 34.73%. Compared with the model group, the increased MDA level was significantly reversed in the positive control group (p<0.01). The content of MDA was reduced in a dose-dependent manner in each of the JGT administration group (p<0.05), and their antioxidant enzyme GSH-Px activities increased (p<0.05). Among which, the MDA content in the high-dose group was reduced to 1.74 nmol/mg, and the GSH-Px activity increased to 828.81 U/mg pro. H&E staining results showed that alcohol-induced liver injury was effectively alleviated by JGT pretreatment. Accordingly, JGT has a certain preventive and protective effect on ALD.
