Abstract:A mouse model of chronic organophosphorus poisoning was first established. Subsequently, after 30 days of oral administration of Lactobacillus plantarum fermentation broth, the cholinesterase (ChE) activity in the brain and blood, the reactive oxygen species (ROS) content in brain tissue, the total superoxide dismutase (T-SOD) activity in liver and serum, and the malondialdehyde (MDA) content in liver and brain were determined. Histopathological examination of the liver and brain tissue was carried out to evaluate the detoxification and protective effects of Lactobacillus plantarum against chronic organophosphorus poisoning in mice. Results showed that in L. plantarum Z3-treated mice, the ChE activity in the mouse blood and brain increased by 36.13% and 81.13%, respectively, and the T-SOD activity in the serum and liver increased by 56.93% and 65.14%, respectively, when compared with the model control group. On the contrary, lower MDA and ROS contents were observed in the treatment groups. The contents of MDA and ROS in the serum and the contents of T-SOD in the liver and brain were respectively decreased by 28.91%, 16.46%, and 15.92% compared to those observed in the model group. After the treatment, the damage to liver cells was significantly alleviated, the morphology of brain nerve cells, neurons, and glial cells returned to normal, and the cells attained an orderly arrangement again. It is concluded that Lactobacillus plantarum can partially repair the body damage caused by chronic organophosphorus poisoning from pesticides, and a certain degree of detoxification is confirmed.
