Regulatory Effects of Complex Probiotics Preparation on Composition of Human Intestinal Microbiota
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Abstract:
To study the regulation effects of complex probiotics on human intestinal microbiota, 15 healthy volunteers were recruited to intake the synthesized complex probiotics for four consecutive weeks, and high-throughput 16S rDNA amplicon sequencing was performed to analyze the changes in the composition of the intestinal microbiota in their stool samples before and after the intake of complex probiotics. The sequencing results revealed that the Shannon and Evenness indices of human intestinal microbiota remain unchanged after four weeks of compound probiotics intake (p>0.05). However, the relative abundance of two phyla, namely Firmicutes and Actinobacteria, was found to be increased. Similarly, at the genus level, the relative abundance of Lactobacillus and Bifidobacterium increased. Additionally, the relative abundance of intestinal hydrogen-producing bacteria, such as Collinsella, Ruminococcus, Dorea, and Eubacterium was also influenced. Conclusively, the intestinal microbiota can be regulated by the synthesized complex probiotics and the relative abundance of some beneficial bacteria in the intestinal tract is thereby increased.
