Toxicology Evaluation of Pandanus amaryllifolius Roxb Powder
Article
Figures
Metrics
Preview PDF
Reference
Related
Cited by
Materials
Abstract:
The subchronic toxicity of Pandanus amaryllifolius Roxb. powder on rats was evaluated, which was expected to provide toxicological safety basis for the development of food additions. The rats were randomly divided into the control group and Pandanus amaryllifolius Roxb. powder samples of low dose group (2.00 g/kg BW), middle dose group (4.00 g/kg BW), high dose group (8.00 g/kg BW), using the oral toxicity test method according to GB 15193.13-2015 in this study. There were 20 rats in each group, half male and half female. Oral toxicity of Pandanus amaryllifolius Roxb. powder was assessed by general clinical observation, weight and feeding, eye examination, hematology and biochemistry, urine examination, gross anatomy and histopathology. During the experiment, the rats’ growth was good. There were no significant differences in body weight, weight gain, food utilization rate, blood routine indexes, blood biochemical indexes, blood coagulation function indexes, organ weight and organ/body weight ratio among each Pandanus amaryllifolius Roxb. powder dose group and the control group (p>0.05). No abnormal changes were observed in routine urine, ophthalmoscopics, gross anatomy and histopathology. The no observed adverse effect levels (NOAEL) of Pandanus amaryllifolius Roxb. powder dose were 8.89 g/kg BW in male and 9.76 g/kg BW in female. There was no subchronic toxicity of Pandanus amaryllifolius Roxb. powdersamplesto rats in this study.
