Hypolipidemic Effects of Shan Qing Camellia nitidissima Tea on Hyperlipidemic Mice
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Abstract:
To obtain a scientific basis for the development and application of Shan Qing Camellia nitidissima tea, its effects on the body weight, lipid profile, and liver functions of hyperlipidemic mice were investigated. In total, 40 C57BL/6 male mice were randomly divided into the following five groups: a blank control group, model group, positive control group, low-dose Shan Qing Camellia nitidissima tea-treated group, and high-dose Shan Qing Camellia nitidissima tea-treated group. The blank control group was fed with ordinary feed, whereas the other groups were fed a high-fat feed. The body weight, liver weight, and serum lipid levels as well as the superoxide dismutase (SOD) activity and malondialdehyde (MDA) level in the liver of each mouse were measured after 8 weeks of oral administration of the tea. The results showed that the total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in the mice treated with the tea were 20%, 16.08%, and 21.54% lower, respectively, than the levels in the model group of mice. Additionally, the high-density lipoprotein cholesterol (HDL-C) content had increased by 27.60%, whereas the atherosclerosis index (AI) and liver index had decreased significantly in the tea-treated mice. Moreover, the SOD activity had increased by 19.29%, whereas the MDA content in the liver had decreased by 16.27%. Obviously, Shan Qing Camellia nitidissima tea can regulate the lipid levels of hyperlipidemic mice and protect their liver.
