Mechanism of Anti-inflammatory Effect of Radix glehniae Based on Network Pharmacology
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Abstract:
Radix glehniae, the dry root of Glehnia littoralis, can be used as medicine and food. It has been used to clear lung heat, to relieve cough and to moisten lung in clinical application. Pharmacological research shows that it possesses anti-bacterial, anti-inflammatory and anti-oxidative effects. However, the molecular mechanism of its anti-inflammatory effect is still not clear. In this study, the databases of TCMSP, PubChem, SEA, UniProt, GeneCards were used to collect the active compounds of Radix glehniae, the corresponding targets of these active compounds and the anti-inflammatory targets. The molecular target network was also constructed using the active components and anti-inflammatory target based on the network nodes. Furthermore, the protein-protein interactions, GO enrichment and KEGG enrichment were analyzed based on the network node. Eight components, such as quercetin, β-sitosterol and stigmasterol were obtained as the active components of Radix glehniae. There were 92 anti-inflammatory targets, including JUN, CASP3, EGFR, AKT1, HSP90AA1, TGFB1, PGR, MET, PLAU, PIM1, and PIK3R1, which are involved in pathways, such as estrogen signaling pathway, IL-17 signaling pathway, EGFR tyrosine kinase inhibitor resistance pathway, AGE-RAGE signaling pathway, PI3K-Akt signaling pathway etc. The characteristics of multi-components, multi-targets and multi-pathways for Radix glehniae can provide a new way and direction for further study on anti-inflammatory mechanism.
