Intestinal Probiotic Function and Antioxidant Capacity-enhancing Effect of An Ethanolic Extract of Radix pseudostellariae
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Abstract:
In this study, D-galactose model mice were used to investigate the relationship between in vivo antioxidation and intestinal probiotic function of an ethanol extract of Radix pseudostellariae. Seventy-two ICR mice were selected and divided into 6 groups. D-galactose was used to induce damage, and a Pseudostellariae ethanol extract was used to intervene to investigate its effect on the growth, antioxidant enzyme activities and intestinal function of the mice. The results showed that the Radix pseudostellariae extract after purification by resin D101 contained saponins (613.48 mg/g dry weight). Compared with the model group, the activities of SOD, CAT and GSH-px of the liver of the HPEs group increased by 16.64%, 26.01% and 20.30%, respectively, with the activities of SOD, CAT and GSH-px of the kidney increasing by 19.94%, 23.37% and 18.00%, the activities of SOD, CAT and GSH-px of the brain increasing by 14.55%, 13.06% and 40.72%, respectively. By increasing the abundance of beneficial bacteria such as Bifidobacterium, Lactobacillus, Bacteroides and Blautiain the intestines, and decreasing the abundance of harmful bacteria such as Methylobacterium, Rikenella and Paraprevotella, the extract could reduce the risk of intestinal diseases, restore the structure of the small intestinalvilli and enhance effectively the body’s antioxidant level.
