Short-term Oral Administration of Inulin can Improve the Fatigue Resistance of Mice
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Abstract:
In this study, the effects of inulin on improving mouse's anti-fatigue and intestinal flora-regulating effects were investigated. The mice were administered orally at low (0.4 mg/kg) and high (2 mg/kg) doses of inulin for 45 days. Thirty minutes after the last administration, the time of weight-loaded swimming was recorded, and the serum creatine kinase (CK) activity, the blood urea nitrogen (BUN) and lactic acid (LA) contents and the fecal flora composition of mice were measured after the forced swimming. The results showed that the weight-loaded swimming times of the low-dose and high-dose groups increased by 45.62% and 90.52%, respectively, compared with the blank group (p<0.05). After strenuous exercise, compared with the blank group, the CK activities of the low-dose group and high-dose group decreased to 17.07% and 53.65% (p<0.05), respectively, with their BUN contents decreasing by 68.70% and 81.28% (p<0.05), respectively, and LA contents decreasing to 16.29% and 41.85% (p<0.05), respectively. In terms of regulating the gut microbiota, compared with the control group, the harmful bacteria (Proteobacteria) in the intestinaltract were down-regulated in the administration group. The experimental results showed that inulin has a significant anti-fatigue effect and regulatory effect on intestinal flora abundance.
