Okra Polysaccharides Improve Glucose and Lipid Metabolism and Kidney Damage in Diabetic Rats
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Abstract:
The effects of okra polysaccharides on glucose and lipid metabolism and renal pathological changes in diabetic rats were investigated in the present study. The rat model of diabetes was constructed by intra peritoneal injection of streptozotocin. The successfully modeled diabetic rats were randomly divided into a model group, metformin group, and low-, medium- and high-dose okra polysaccharide groups. The okra polysaccharides were administered continuously for 28 days, the levels of blood glucose and serum lipids as well as renal pathological changes in all groups of rats were determined, while the effect of okra polysaccharides on the activity of α-glycosidase was measured by the pNPG method. The results showed that compared with the model group, the levels of fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) of the okra polysaccharides-treated groups decreased, with the greatest reduction occurring to the high-dose group (decreased by 32.80% and 17.87%, respectively). In terms of blood lipids, compared with the model group, the total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) of the okra polysaccharides-treated groups decreased, with the high-dose group having the greatest decrease (by 21.55%, 38.98%, 40.70%, respectively). The high density lipoprotein (HDL) contents increased for all groups, with the highest increase of 47.46% in the high-dose group.In the meantime, the okra polysaccharides could significantly inhibit the activity of α-glucosidase, with the inhibition rate increasing with an elevated dose. When the polysaccharide concentration was 10 mg/mL, the inhibition rate was 68.26%. The okra polysaccharides can alleviate glomerular atrophy and renal tubule swelling in diabetic rats. Therefore, okra polysaccharides can improve blood glucose and lipid levels, and can improve renal pathological changes in diabetic rats. Okra polysaccharides have broad prospects in the development of hypoglycemic dietary supplements, health foods and hypoglycemic drugs. Okra polysaccharide can improve the blood sugar and blood lipid level of diabetic rats, and improve the pathological changes of the kidney tissue of diabetic rats. It has broad prospects in the development of hypoglycemic dietary supplements, health foods and hypoglycemic drugs.
