Meta-analysis of the Mechanism of Walnut Kernel against Type 2 Diabetes
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Abstract:
The intervention mechanism of walnut kernel on type 2 diabetes was investigated by meta-analysis in this study. TCMSP database was used to screen the main active ingredients and potential targets of walnut kernels. Targets for type 2 diabetes-related diseases were searched in the OMIM, TTD and genecards databases, and the active component targets and disease targets were intersected using R3.6.2 software. A network diagram was constructed using cystoscope 3.7.2 software. The analyses of protein interaction, GO function and KEGG pathway enrichment were performed on the intersection targets through STRING. As a result, 83 targets of 11 active ingredients, such as gallic acid, gallic tannins and pentagalloylglucose were obtained, which were intersected with 3015 targets related to type 2 diabetes to obtain 28 targets of walnut component for type 2 diabetes intervention, mainly including dioxygenase 2, coagulation factor 2, and catalase, IL5 and glucose-6-phosphate 1-dehydrogenase. These targets involved GO functions such as hormone metabolism, cellular lipid metabolism, fatty acid biosynthesis and cholesterol metabolism, and in vitro and in vivo responses to organic and inorganic substances, which participated mainly in four categories of disorders, diabetes, cancer, circulatory system and inflammation, along with 17related pathways, as well as KEGG pathways such as endocrine, signal transduction, thyroid and neurotransmitter. The results showed that walnut kernels may participate in lipid metabolism regulated by signaling pathways such as MAPK, AGE-RAGE and PI3K-Akt signaling pathways with multiple targets such as PRKD1, PRKCA,PRKCB, PRKCE, PRKCZ, IL5, F2, CAT, and G6PD, to achieve type 2 diabetes intervention effects.
