Dual Inhibitory Effects of Aqueous Tree Peony (Paeonia suffruticosa Andr.) Extract on Renin and ACE
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Abstract:
The inhibitory effects of aqueous tree peony (Paeonia suffruticosa Andr.) extracts on renin and angiotensin converting enzyme (ACE), two key enzymes in the renin-angiotensin system, were investigated in this research. Tree peony samples with typical colors were selected and compared with herbaceous peony (Paeonia lactiflora Pall.) samples on the renin- and ACE-inhibitory activities and antioxidant activities of aqueous sample extracts were determined. The correlations between the contents of total phenolics or flavonoids and the functionalities were also analyzed. Results showed that the aqueous extracts of red tree peony and herbaceous peony exhibited excellent renin- and ACE-inhibitory activities, while the aqueous extract of white tree peony exhibited very weak inhibitory effects on renin and ACE activities. The IC50 value of the extract with the highest inhibitory activity was 0.08 mg/mL for renin and 0.23 mg/mL for ACE. In addition, the aqueous extracts of red tree peony and herbaceous peony had ABTS free radical scavenging capacities in the range of 115.89~121.75 mg TE/g DW, DPPH radical scavenging capacities in the range of 192.67~200.46 mg TE/g DW, iron ion reduction capacities in the range of 119.86~208.94 mg TE/g DW, and total phenolic content in the range of 99.29~122.45 mg GAE/g DW. However, the antioxidant capacity and total phenolic content of the white tree peony extracts were much lower than those of the red ones. Correlation analysis revealed that the renin-/ACE-inhibitory activities, DPPH/ABTS free radical scavenging capacities, and iron reduction ability of the different aqueous extracts were significantly positively correlated with their total phenolic contents (p<0.01), with the correlation coefficients being 0.99, 0.91, 0.99, 0.99 and 0.98, respectively. This research indicated that the aqueous extracts of the dark colored tree peony tended to show stronger renin-and ACE-inhibitoryactivities, with phenolic compounds as potentially important active substances. These results would provide more fundamental theoretical support for exploring novel blood pressure-regulating agents and fulfilling the high-value utilization of various tree peony flowers.
