Puerarin Improves Oxidative Stress in Rats with Gestational Diabetes Mellitus

Abstract:

The effect of puerarin extract on oxidative stress in gestational diabetes model rats was studied. Gestational diabetes model rats were established and puerarin extract was used for intervention. Fasting blood glucose (FPG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor (TNF-α), Quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and nuclear factor E2 related factor 2 (Nrf2) proteins were detected. Results were showed that the FPG, LDL-C and HDL-C of high dose puerarin group were 9.05 mmol/L, 0.79 mmol/L and 0.72 mmol/L respectively, which were significantly different with other groups (p<0.05). The MDA, NO and SOD were 7.15 nmol/mg, 90.76 μmol/L and 9.29 U/mg respectively, The levels of IL-6, CRP and TNF-α in puerarin high-dose group were 135.51 ng/L, 7.18 mg/L and 15.06 μg/μL respectively, which were lower than those in model groups (p<0.05). Puerarin extract can reduce fasting blood glucose and improve MDA, NO and SOD levels.