Regulatory Effect of Pea Oligopeptide on PI3K/AKT/FOXO1 Signaling Pathway in Liver of Type 2 Diabetic Mice
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Abstract:
The purpose of this study was to investigate the effect of pea oligopeptide on the protein expression of phosphatidylinositol 3-kinase/protein kinase B/FoxO1 (PI3K/ AKT/ FoxO1) in the liver of mice with type 2 diabetes mellitus (T2MD). Mice were intraperitoneally injected with streptozotocin (STZ) to establish a type 2 diabetic mouse model, and the mice were fed with metformin and pea oligopeptide for 4 weeks, respectively. The results showed that the diabetes indications of mice in the pea oligopeptide group were improved in a dose-dependent manner compared with the model group. In the high-dose group, blood glucose was decreased by 23.97%, body weight were increased by 12.24%, and the expressions of PI3K, AKT and FOXO1 proteins in the liver were increased by 278.49%, 21.78% and 80.41%, respectively. Cytopathological observation showed that the high dose group could regulate cell morphology and improve glycogen accumulation. Therefore, pea oligopeptidatin can regulate the PI3K/AKT/FOXO1 signaling pathway in the liver of mice with type 2 diabetes, which can not only reduce liver cell damage, but also improve some indicators of type 2 diabetic mice. This paper broadens the idea of high-value utilization of pea protein, and provides practical reference for the application of pea oligopeptide in the field of diabetes, which can supplement and improve the diabetes theory of pea oligopeptide.
